New York Mets (49-30, first in the NL East) vs. Cincinnati Reds (27-51, fifth in the NL Central)
Cleveland Guardians (40-36, second in the AL Central) vs. Detroit Tigers (30-47, fourth in the AL Central)
Minnesota Twins (45-37, first in the AL Central) vs. Chicago White Sox (38-39, third in the AL Central)
Chicago Cubs (32-47, third in the NL Central) vs. Milwaukee Brewers (46-35, first in the NL Central)
St. Louis Cardinals (44-37, second in the NL Central) vs. Atlanta Braves (46-34, second in the NL East)
Texas Rangers (37-40, third in the AL West) vs. Baltimore Orioles (36-44, fifth in the AL East)
Colorado Rockies (35-44, fifth in the NL West) vs. Los Angeles Dodgers (49-29, first in the NL West)
Seattle Mariners (39-42, second in the AL West) vs. San Diego Padres (47-34, second in the NL West)
Miami Marlins (37-40, fourth in the NL East) vs. Washington Nationals (29-52, fifth in the NL East)
Tampa Bay Rays (43-36, fourth in the AL East) vs. Boston Red Sox (44-35, second in the AL East)